
Amelparib hydrochloric hydrate
CAS No. 1449233-60-6
Amelparib hydrochloric hydrate( JPI-289 | JPI289 )
Catalog No. M11930 CAS No. 1449233-60-6
Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
Purity : >98% (HPLC)






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Biological Information
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Product NameAmelparib hydrochloric hydrate
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NoteResearch use only, not for human use.
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Brief DescriptionAmelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
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DescriptionAmelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.Stroke Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsJPI-289 | JPI289
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research AreaNeurological Disease
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IndicationStroke
Chemical Information
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CAS Number1449233-60-6
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Formula Weight452.373
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Molecular FormulaC19H31Cl2N3O5
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Purity>98% (HPLC)
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Solubility——
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SMILESCCOC1=CC(=CC2=C1C3=C(CCCN3)C(=O)N2)CN4CCOCC4.O.O.Cl.Cl
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Chemical Name10-ethoxy-8-(morpholinomethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one dihydrochloride dihydrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679.
2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.
molnova catalog



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