Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - PARP - Amelparib hydrochloric hydrate

Amelparib hydrochloric hydrate

CAS No. 1449233-60-6

Amelparib hydrochloric hydrate( JPI-289 | JPI289 )

Catalog No. M11930 CAS No. 1449233-60-6

Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Amelparib hydrochloric hydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
  • Description
    Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.Stroke Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JPI-289 | JPI289
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Neurological Disease
  • Indication
    Stroke

Chemical Information

  • CAS Number
    1449233-60-6
  • Formula Weight
    452.373
  • Molecular Formula
    C19H31Cl2N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCOC1=CC(=CC2=C1C3=C(CCCN3)C(=O)N2)CN4CCOCC4.O.O.Cl.Cl
  • Chemical Name
    10-ethoxy-8-(morpholinomethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one dihydrochloride dihydrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679. 2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 4-amino-1,8-Naphthal...

    4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM.

  • SRI-011381

    SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.

  • 5-amino-1,2-dihydroi...

    5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.

Sign In Join Free